This study found a surprising lack of toxicity from chlorine dioxide administered in a number of different ways. Like eye drops, in vitro cell tests, inhalation tests, and oral tests.
But this was for pure chlorine dioxide solution. They noted that some impurities resulting from unpurified chlorine dioxide (obtained by mixing sodium chlorite and hydrochloric acid for example) would have toxicity, so these result were only for purified chlorine dioxide solution.
For the oral test, mice were given drinking water that had 40 ppm chlorine dioxide (therapeutic dosage level!) for 90 days. In other words, every drop of water they drank for 90 days had 40 ppm chlorine dioxide.
"UC-1" is what they call their purified chlorine dioxide solution.
3.6. Subchronic Oral Toxicity Test
In the subchronic oral toxicity test, 0, 5, 10, 20, and 40 ppm UC-1 was prepared to feed the mice. Clinical observations of the mice showed no abnormality and no mortality after 90 days for the control and test groups (Table 5). The mouse weight was not influenced (Figure 5). Moreover, necropsy and gross examination did not show any pathological symptoms. The weights of the heart, liver, spleen, and kidney of the test groups did not differ significantly compared with those in the control group. Therefore, administration of up to 40 ppm UC-1 to mice for 90 days is nontoxic.
But this was for pure chlorine dioxide solution. They noted that some impurities resulting from unpurified chlorine dioxide (obtained by mixing sodium chlorite and hydrochloric acid for example) would have toxicity, so these result were only for purified chlorine dioxide solution.
For the oral test, mice were given drinking water that had 40 ppm chlorine dioxide (therapeutic dosage level!) for 90 days. In other words, every drop of water they drank for 90 days had 40 ppm chlorine dioxide.
"UC-1" is what they call their purified chlorine dioxide solution.
3.6. Subchronic Oral Toxicity Test
In the subchronic oral toxicity test, 0, 5, 10, 20, and 40 ppm UC-1 was prepared to feed the mice. Clinical observations of the mice showed no abnormality and no mortality after 90 days for the control and test groups (Table 5). The mouse weight was not influenced (Figure 5). Moreover, necropsy and gross examination did not show any pathological symptoms. The weights of the heart, liver, spleen, and kidney of the test groups did not differ significantly compared with those in the control group. Therefore, administration of up to 40 ppm UC-1 to mice for 90 days is nontoxic.