Helpful Info. What's the deal with hydroxychloroquine and Z-pak?

[DrHenley]

As best at I can determine, this is why hydroxychloroquine and Z-pak are being touted as miracle cures for COVID-19

What kills most people with COVID-19 is what's called a "cytokine storm." It is an overreaction of the body's immune system in which the immune system starts destroying healthy cells along with viruses. One of the things that gets destroyed is the ACE2 receptors in the lungs. These regulate blood pressure, so that causes dangerously high blood pressure. People who are most susceptible to high blood pressure are the most susceptible to dying suddenly from COVID-19.

Zinc can disrupt the cytokine storm.

Zinc deficiency is common among the elderly because the body's rate of zinc absorption decreases with age.

Hydroxychloroquine increases the amount of zinc cells can absorb (among other things)

Z-Pak, an antibiotic (generic name azithromycin), kills bacteria by inhibiting mRNA, which inhibits the ability of bacteria to make proteins. SARS-COV-2, the virus that causes COVID-19, is an RNA virus. So Z-Pak inhibits the ability of the virus to replicate.

Hydroxychloroquine + Z-Pak + Zinc seems to be the most effective treatment for COVID-19, with some doctors claiming a 100% recovery rate in their patients within days.

Hydroxychloroquine was approved by the FDA in 1955.
Azithromycin was approved by the FDA in 1988.

Both drugs have been used frequently for decades, and were also used to fight SARS. We know the side effects.

 

[KateMTx]

I have read about other drugs that disrupt cytokine storm (used for individuals with the flu who sometimes develop it, and with certain immunotherapies which often cause cytokine storm). According to Wikipedia these are also being tested with COVID-19. I think there is hope for effective treatments for the worst effects of the disease. Unfortunately none of these are a "miracle cure" but I think they are being tested and used more and more as doctors and health officials realize that they have to offer something, even it hasn't yet passed rigorous clinical trials.

 

[Kevin L]

Thank you for letting us know about this, Doctor H.

I still believe in prevention over cure, though. These drugs are very powerful, and can be dangerous if they're misused. The issue I have is with people who may not have insurance, have lost their jobs and are feeling scared and desperate taking these meds indiscriminately, and causing themselves (or their children) to go into kidney and/or liver failure, get brain damage, become deaf, and so on.

These meds can be found on the Internet, but the other problem is that unscrupulous people may be selling counterfit versions of these meds, or meds that might be made in an underground lab with sloppy quality control . . . and laced with dangerous contaminants.

As an example from my own experience as a paramedic, in the 1980s and early 90s, there was a synthetic form of heroin that was flooding the streets that caused an instant (and permanant) form of Parkinson's disease even if it was used only one time. This happened because the DEA was very successful at intercepting and destroying drug shipments to the United States, so--to address the shortage--the dealers turned to black market chemists to make a substitute from scratch. This problem is somewhat similar (in principle) to the Fentanyl that's used to cut heroin today.

I have a concern that frightened people--hearing this news--will start using this combination of drugs without medical supervision and/or adequate quality control, and that this may cause more deaths than the disease itself.

My next concern is that people will use these meds indiscriminately and--somehow--convince themselves that they are protected from the corona virus, and slack off on masks, handwashing, and social distancing . . . all of which may, paradoxically, make the epidemic worse.

One last concern is that people who need these meds for other chronic conditions (lupus, for example, is treated with chloroquine) will be unable to get these meds, and will turn to black market sources . . . which brings us right back to my first concern about contaminants and quality control . . . which may be ten times worse for patients who have chronic, underlying medical conditions already.

I'm not asking everyone to agree with me, but can you see my points? I sometimes have problems communicating.

 

[DrHenley]

Kevin, I am in no way shape or form advocating self medication with prescription drugs.

 

[Kevin L]

Kevin, I am in no way shape or form advocating self medication with prescription drugs.

I understand, and I wasn't suggesting that you were. If I created that impression, then I wish to publically apologize.

I was just trying to voice concerns that I have about this thing . . . as I have devoted much of my career to saving peoples' lives, and it bothers me when talking heads on the news (or politicians) throw out things like this without recognizing that there are real-world consequences.

I was just venting my concerns and frustrations.

 

[Proud Prepper]

Thank you for letting us know about this, Doctor H.

I still believe in prevention over cure, though. These drugs are very powerful, and can be dangerous if they're misused. The issue I have is with people who may not have insurance, have lost their jobs and are feeling scared and desperate taking these meds indiscriminately, and causing themselves (or their children) to go into kidney and/or liver failure, get brain damage, become deaf, and so on.

These meds can be found on the Internet, but the other problem is that unscrupulous people may be selling counterfit versions of these meds, or meds that might be made in an underground lab with sloppy quality control . . . and laced with dangerous contaminants.

As an example from my own experience as a paramedic, in the 1980s and early 90s, there was a synthetic form of heroin that was flooding the streets that caused an instant (and permanant) form of Parkinson's disease even if it was used only one time. This happened because the DEA was very successful at intercepting and destroying drug shipments to the United States, so--to address the shortage--the dealers turned to black market chemists to make a substitute from scratch. This problem is somewhat similar (in principle) to the Fentanyl that's used to cut heroin today.

I have a concern that frightened people--hearing this news--will start using this combination of drugs without medical supervision and/or adequate quality control, and that this may cause more deaths than the disease itself.

My next concern is that people will use these meds indiscriminately and--somehow--convince themselves that they are protected from the corona virus, and slack off on masks, handwashing, and social distancing . . . all of which may, paradoxically, make the epidemic worse.

One last concern is that people who need these meds for other chronic conditions (lupus, for example, is treated with chloroquine) will be unable to get these meds, and will turn to black market sources . . . which brings us right back to my first concern about contaminants and quality control . . . which may be ten times worse for patients who have chronic, underlying medical conditions already.

I'm not asking everyone to agree with me, but can you see my points? I sometimes have problems communicating.

You cant fix stupid, so I would stop trying to.

 

[TexasFreedom]

You cant fix stupid, so I would stop trying to.

I think Rellgar is making a huge point.

Let me give examples. I don't think they should put fencing around the Grand Canyon. Anyone stupid enough to get close to the edge, falling to their death... well let them take their genetics out of the breeding pool. Another example: I don't think laws should require adult motorcycle riders to wear helmets. They ride, they crash, they die, again taking out their genetic stupidity. I'm not saying a sign saying "DANGER-Cliff Edge ahead" or encouraging wearing helmets aren't reasonable or good.
(ok, don't be eating or drinking with these next sentences)
And to use your same logic, I don't have a worry that people thinking that we didn't fence the Grand Canyon means we don't need fences around prisons. Nor do I worry that helmet laws will make people think a motorcycle helmet will protect them when they go diving. And we don't need signs saying "please don't lick the toilet seats".

Stupid seems to always be with us. Not talking about something that appears to be an effective treatment because idiots will drink fish-tank cleaner is more dangerous than not talking about it. Do not inhibit the world to protect the Stupid, just let Stupid take itself out.

 

[DrHenley]

I think Rellgar is making a huge point.

Let me give examples. I don't think they should put fencing around the Grand Canyon. Anyone stupid enough to get close to the edge, falling to their death... well let them take their genetics out of the breeding pool.

Last time I was at the Grand Canyon, people were ignoring the fences and climbing out on narrow projections (less then two ft wide) with 1000 ft drops on either side.

 

[DrHenley]

I found a US Government database of clinical trials.

Clinical trials with hydroxychloroquine
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine&cond=COVID-19

Clinical trials with both hydroxychloroquine and zinc
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine+zinc&cond=COVID-19

There are only 5 clinical trials listed using a combination of HCQ and zinc. One in the UK, one in Turkey, and three in the US. The clinical trial in Turkey is recruiting subjects, and the other 4 are not yet recruiting subjects for the trial.

There are ZERO clinical trials underway using both HCQ and zinc!

NONE - ZIP ZERO NADA!


WHY WHY WHY?????????

 

[Proud Prepper]

I found a US Government database of clinical trials.

Clinical trials with hydroxychloroquine
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine&cond=COVID-19

Clinical trials with both hydroxychloroquine and zinc
https://clinicaltrials.gov/ct2/results?term=hydroxychloroquine+zinc&cond=COVID-19

There are only 5 clinical trials listed using a combination of HCQ and zinc. One in the UK, one in Turkey, and three in the US. The clinical trial in Turkey is recruiting subjects, and the other 4 are not yet recruiting subjects for the trial.

There are ZERO clinical trials underway using both HCQ and zinc!

NONE - ZIP ZERO NADA!


WHY WHY WHY?????????

Big Pharma and corrupt government officials is why.

 

[Kevin L]

You cant fix stupid, so I would stop trying to.

The ways that people find to be stupid never cease to amaze me.

I sometimes wonder how many of our laws and customs are predicated on the existence of stupidity.

 

[DrHenley]

Two studies are of the most interest to me

The one in Turkey which has already recruited subjects:
Proflaxis for Healthcare Professionals Using Hydroxychloroquine Plus Vitamin Combining Vitamins C, D and Zinc During COVID-19 Pandemia: An Observational Study
Testing the combination of
Hydroxychloroquine
Vitamin C
Vitamin D
Zinc

And the one in Ventura California, which hasn't recruited subjects yet.
A Study of Quintuple Therapy to Treat COVID-19 Infection (HAZDpaC)
Testing the combination of
Hydroxychloroquine
Azithromycin
Vitamin C
Vitamin D
Zinc

 

[DrHenley]

I have posted this in another thread, but I need to post it in this thread. These are National Institutes of Health articles about the roles of zinc and chloroquine in the treatment of coronaviruses. This is "established science" folks.

The role of zinc in disrupting Coronavirus replication:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973827/
The role of zinc in disrupting cytokine storms:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407988/
The role of chloroquine (and by extension hydroxychloroquine) in increasing the uptake of zinc in cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

 

[DrHenley]

I contacted Brietbart News and asked them to find out what's going on with the HCQ and Zinc clinical trials. I figure they would be more interested in the truth than ABC/CBS/CNN/NBC/NYT/MSNBC/etc.

 

[DrHenley]

Ooo now this is what I like to see!

A clinical trial in Tunisia.
https://clinicaltrials.gov/ct2/show...ychloroquine+zinc&cond=COVID-19&draw=2&rank=2

Three groups:

Hydroxychloroquine & Zinc
Hydroxychloroquine & Zinc Placebo
Hydroxychloroquine Placebo & Zinc Placebo.

Detailed Description: The study is a multicenter randomized controlled double blind clinical trial, including up to 660 military health professionals working in Tunisia and exposed to SARS CoV2 at different levels (2 levels of exposure).

The trial will assess the efficacy of hydroxychloroquine associated to Zinc compared to hydrxyochloroquine. Randomization will be performed by IWRS (Interactive Web Response System) by random double blocs of 9 and 6.


SOMEBODY is thinking scientifically FINALLY!

 

[DrHenley]

So I started trying to look at clinical trials of HCL without zinc, and there are over 200. Why they would give HCL without zinc I have no idea, but...

So here is one of those clinical trials that got suspended over the "concerns about adverse effects."
https://clinicaltrials.gov/ct2/show/NCT04371926?term=hydroxychloroquine&cond=COVID-19&draw=2&rank=29

I looked at the dosage. HOLY MOLY they were giving 600% of the recommended dose of HCL. WELL Geez Louise, yeah, I'd be concerned about adverse effects too!!!!

So instead of continuing to try to OD people on HCL they withdrew the study.

 

[DrHenley]

Just to show you how "smart" these doctors and scientists are.

WE KNOW that zinc has the ability to disrupt coronavirus replication, and disrupt cytokine storms. We've known that for many years. (See links in posts above)

We also know that hydroxychloroquine has the ability to increase the uptake of zinc in cells. We've known that for ten years at least.

It is the zinc that does the heavy lifting, hydroxychloroquine is just the "enabler" for zinc.

So you'd think that a "smart" doctor or scientist would be studying the effects on COVID-19 of the combination of hydroxychloroquine and zinc, BEFORE a cytokine storm has already occurred, right?

ClinicalTrials.gov shows 239 studies being conducted on the effects of hydroxychloroquine on COVID-19.
https://clinicaltrials.gov/ct2/resu...=hydroxychloroquine&cntry=&state=&city=&dist=
Guess how many include zinc? 9
https://clinicaltrials.gov/ct2/resu...oxychloroquine+ZINC&cntry=&state=&city=&dist=
So why are these "genius" doctors and scientists doing 230 studies on hydroxychloroquine and COVID-19 that do not include zinc???

 

[Proud Prepper]

Just to show you how "smart" these doctors and scientists are.

WE KNOW that zinc has the ability to disrupt coronavirus replication, and disrupt cytokine storms. We've known that for many years. (See links in posts above)

We also know that hydroxychloroquine has the ability to increase the uptake of zinc in cells. We've known that for ten years at least.

It is the zinc that does the heavy lifting, hydroxychloroquine is just the "enabler" for zinc.

So you'd think that a "smart" doctor or scientist would be studying the effects on COVID-19 of the combination of hydroxychloroquine and zinc, BEFORE a cytokine storm has already occurred, right?

ClinicalTrials.gov shows 239 studies being conducted on the effects of hydroxychloroquine on COVID-19.
https://clinicaltrials.gov/ct2/resu...=hydroxychloroquine&cntry=&state=&city=&dist=
Guess how many include zinc?
9
https://clinicaltrials.gov/ct2/resu...oxychloroquine+ZINC&cntry=&state=&city=&dist=
So why are these "genius" doctors and scientists doing 230 studies on hydroxychloroquine and COVID-19 that do not include zinc???

That's an easy one. They were told, coerced, persuaded by big pharma to not include it, so there left controlled media can broadcast that it doesn't work. This will fool most people. Even those who believe in a consences will see the vast majority of trials show HDQ is effective.

 

[Joe SA]

That's an easy one. They were told, coerced, persuaded by big pharma to not include it, so there left controlled media can broadcast that it doesn't work. This will fool most people. Even those who believe in a consences will see the vast majority of trials show HDQ is not effective.

Knowing that, does that make them complicit in murder?

 

[JackDW]

As with anything else with this vius, it is political. Trump touted

hydroxychloroquine so the corrupt media and liberal progressives (actually regressives) have to prove

hydroxychloroquine does not work, at any costs. And they have found out that "so called" experts are cheap. ​

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