This is the most informative article I've seen. It talks about several things I have suspected all along but never saw anywhere in print. Apparently there are still some real investigative journalists out there that bother to dig for important information from genuine experts and are able to coherently present it!
https://www.greenwichtime.com/news/article/Second-week-crash-is-time-of-peril-for-some-15234540.php
'Second-week crash' is time of peril for some covid-19 patients
For people who suffer the most severe reactions to the novel coronavirus - and their caregivers - the second week of the disease can become a time of sudden peril and heightened concern, when some of those who seem stable or mending can suddenly become critically ill.
There is little consensus among doctors and experts about why days five through 10, or thereabouts, seem to be so dangerous for some people with covid-19, the disease caused by the virus. But everyone from critical care specialists to EMTs is aware of this frightening aspect of the disease.
...
"I've been thinking about this a lot," said Naftali Kaminski, chief of pulmonary critical care and sleep medicine at the Yale School of Medicine, who studies the genomics of lung disease. "There's an early stage of infection and the virus sits somewhere. You can almost look at the virus as a fifth column coming in, securing its stronghold and then slowly inducing more cells to let it in.
"Because of this lurking nature, your genetic makeup and preexisting conditions will affect presentation of the disease," he said.
...
Eytan Raz, a neurointerventional radiologist at NYU Langone Health, said one theory is that some of the blood clotting complications may be due to an over-reactive immune response that comes after the virus has settled in, multiplied and triggered a defensive army of antibodies to fight back.
An April 17 paper in the medical journal, The Lancet, said that covid-19 appears to have the ability to attack the lining of blood vessels anywhere in the body. Frank Ruschitzka, a researcher from University Hospital Zurich, and his co-authors wrote that this may be why so many organs, including the lungs, kidneys and intestines, are affected in patients with severe illness.
It also could explain why people with cardiovascular disease, diabetes and obesity, as well as smokers, are more likely to have severe illness.
Michael Bell, chief of critical care at Children's National Hospital, speculated that this is why the second week crash and covid-19 itself, are rarely seen in children.
"We've had several dozen kids on our medical floor and have been on pins and needles that they were going to have a big collapse after week one. We haven't seen any of that," he said. "My best explanation is children in general have pretty healthy blood vessels."
https://www.greenwichtime.com/news/article/Second-week-crash-is-time-of-peril-for-some-15234540.php
'Second-week crash' is time of peril for some covid-19 patients
For people who suffer the most severe reactions to the novel coronavirus - and their caregivers - the second week of the disease can become a time of sudden peril and heightened concern, when some of those who seem stable or mending can suddenly become critically ill.
There is little consensus among doctors and experts about why days five through 10, or thereabouts, seem to be so dangerous for some people with covid-19, the disease caused by the virus. But everyone from critical care specialists to EMTs is aware of this frightening aspect of the disease.
...
"I've been thinking about this a lot," said Naftali Kaminski, chief of pulmonary critical care and sleep medicine at the Yale School of Medicine, who studies the genomics of lung disease. "There's an early stage of infection and the virus sits somewhere. You can almost look at the virus as a fifth column coming in, securing its stronghold and then slowly inducing more cells to let it in.
"Because of this lurking nature, your genetic makeup and preexisting conditions will affect presentation of the disease," he said.
...
Eytan Raz, a neurointerventional radiologist at NYU Langone Health, said one theory is that some of the blood clotting complications may be due to an over-reactive immune response that comes after the virus has settled in, multiplied and triggered a defensive army of antibodies to fight back.
An April 17 paper in the medical journal, The Lancet, said that covid-19 appears to have the ability to attack the lining of blood vessels anywhere in the body. Frank Ruschitzka, a researcher from University Hospital Zurich, and his co-authors wrote that this may be why so many organs, including the lungs, kidneys and intestines, are affected in patients with severe illness.
It also could explain why people with cardiovascular disease, diabetes and obesity, as well as smokers, are more likely to have severe illness.
Michael Bell, chief of critical care at Children's National Hospital, speculated that this is why the second week crash and covid-19 itself, are rarely seen in children.
"We've had several dozen kids on our medical floor and have been on pins and needles that they were going to have a big collapse after week one. We haven't seen any of that," he said. "My best explanation is children in general have pretty healthy blood vessels."
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